Estradiol (Estrace, Evamist, Vagifem)

Estradiol Review

Use Estrandiol to reduce moderate to severe menopausal symptoms, to treat vulval and vaginal atrophy, treat certain cancers in special situations and prevent the thinning of bones.

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Estradiol Drug Class and Mechanism

Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estradiol binds well to both estrogen receptors, ER? and ER?, in contrast to certain other estrogens, notably medications that preferentially act on one of these receptors. These medications are called selective estrogen receptor modulators, or SERMs. Estradiol is the most potent naturally-occuring estrogen. Recently there has been speculation about a membrane estrogen receptor, ERX.

Estradiol Uses

Estradiol is a hormone and is given to women who no longer produce the proper amount. It is used to reduce menopause symptoms (e.g., hot flashes), for brittle bones (osteoporosis), and treats certain cancers in both men and women.May be taken with food or immediately after a meal to prevent stomach upset. Take Estradiol as prescribed.

Estradiol Side Effects

May cause dizziness, lightheadedness, headache, stomach upset, bloating, or nausea. These effects should disappear as your body adjusts to the medication. Notify your doctor if you experience: severe depression, calf pain, sudden severe headache, chest pain, shortness of breath, lumps in the breast, weakness or tingling in the arms or legs, yellowing of the eyes or skin, changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or complete stoppage of bleeding), stomach pain, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

Estradiol Pregnancy

The effect of estradiol, together with estrone and estriol, in pregnancy is less clear. They may promote uterine blood flow, myometrial growth, sitmulate breast growth and at term, promote cervical softening and expression of myometrial oxytocin receptors.

Estradiol Overdose

Serious ill effects have not been reported following acute ingestion of large doses of estrogen-containing oral contraceptives by young children. Overdosage of estrogen may cause nausea and vomiting, and withdrawal bleeding may occur in females.

Estradiol More Information

You are cautioned to discuss very carefully with your doctor or health care provider all the possible risks and benefits of long-term estrogen and progestin treatment as they affect you personally.